It would take about 1,200,000 mosquitoes to fully drain the average human body of blood.
Interesting mosquito factoid: Male mosquitoes are actually vegetarians: the females suck blood for the protein to produce eggs. Also while a mosquito is feeding there is a chemical signal that stops a mosquito from feeding more once its full. Scientists can disable that signal in a lab, making mosquitoes suck until they explode!
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